Palladium-Catalyzed Unimolecular Fragment Coupling of N-Allylamides Bearing a Tethered Nucleophile with the Translocation of an Amide Group-Reference-Cited by-同舟云学术

Palladium-Catalyzed Unimolecular Fragment Coupling of N-Allylamides Bearing a Tethered Nucleophile with the Translocation of an Amide Group

Published:2023-01-30 Issue:01 Volume:56 Page:134-142
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Tobisu Mamoru¹²^ORCID,Shimazumi Ryoma¹,Kodama Takuya¹²

Affiliation:

1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University

2. Innovative Catalysis Science Division, Institute for Open and Transdisciplinary Research Initiatives (ICS-OTRI), Osaka University

Abstract

AbstractThe palladium-catalyzed reaction of N-allylamides bearing a tethered nucleophile results in the extrusion of an amide moiety in the form of an isocyanate, with its subsequent capture by the pendant nucleophile. This reaction involves the net catalytic transposition of an amide group.

Funder

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2022-1905.pdf

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1. The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

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