Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis

Author:

Pallarés Judith1,Torreguitart Núria2,Arqué Gloria3,Portero-Otin Manuel4ORCID,Purroy Francisco35ORCID

Affiliation:

1. Department of Pathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain

2. Department of Vascular Surgery, Hospital Universitari Arnau de Vilanova, Lleida, Spain

3. Clinical Neurosciences Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain

4. Department of Experimental Medicine, Institut de Recerca Biomèdica de Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain

5. Stroke Unit, Department of Neurology, Hospital Universitari Arnau de Vilanova, Medicine Department, Universitat de Lleida, Lleida, Spain

Funder

Government of Catalonia-Agència de Gestió d'Ajuts Universitaris i de Recerca

Instituto de Salud Carlos III and co-funded by European Union

Diputació de Lleida and IRBLleida funds

INVICTUS plus Research Network

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Reference6 articles.

1. Interferons as essential modulators of atherosclerosis;M CS Boshuizen;Arterioscler Thromb Vasc Biol,2015

2. cGAS in action: expanding roles in immunity and inflammation;A Ablasser;Science,2019

3. The cGAS-STING pathway as a therapeutic target in inflammatory diseases;A Decout;Nat Rev Immunol,2021

4. STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases;P T Pham;Eur Heart J,2021

5. Endothelial cell senescence in human atherosclerosis: role of telomeres in endothelial dysfunction [in Japanese];T Minamino;J Cardiol,2003

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