Vibrational Circular Dichroism Studies on Axially Chiral Carbodiimides and Allenes

Abstract

AbstractThe axial chirality of molecules with two consecutive double bonds (X=Y=Z) has not been well studied because of a lack of analytical methods and because of difficulties in their preparation in enantiomerically pure forms. This Synpacts article describes the use of vibrational circular dichroism spectroscopy to study the stereochemistry of carbodiimides and allenes. A strategy to obtain carbodiimides with one-handed chirality by using conformationally restrained frameworks is also discussed.1 Introduction2 Carbodiimides with Partially Biased Axial Chirality and One-Handed Axial Chirality3 Axially Chiral Allenes4 Conclusions