Author:
Mancheño Olga García,Entgelmeier Lukas-M.
Abstract
AbstractOver the past two decades, enantioselective anion-binding catalysis has emerged as a powerful strategy for the induction of chirality in organic transformations. The stereoselectivity is achieved in a range of different reactions by using non-covalent interactions between a chiral catalyst and an ionic substrate or intermediate, and subsequent formation of a chiral contact ion pair upon anion binding. This strategy offers vast possibilities in catalysis and the constant development of new reactions has led to various substrate activation approaches. This review provides an overview on the different activation modes in asymmetric anion-binding catalysis by looking at representative examples and recent advances made in this field.1 Introduction2 Electrophile Activation by Single Anion-Binding Catalysis2.1 Prior In Situ Charged Electrophiles2.2 Neutral Electrophile Activation via Anion Abstraction2.2.1 Anion Abstraction via an SN1 Mechanism2.2.2 Anion Abstraction via an SN2 Mechanism3 Nucleophile Activation and Delivery4 Bifunctional and Cooperative Co-catalysis Strategies4.1 Amine Groups for Bifunctional and Cooperative Catalysis4.2 Brønsted Acid Co-catalysis4.3 Lewis Acid Co-catalysis4.4 Lewis Base Co-catalysis4.5 Nucleophilic Co-catalysis for Activation of Electrophiles4.6 Cooperative Metal and Anion-Binding Catalysis4.7 Combination of Photoredox and Anion-Binding Catalysis5 Anion-π Catalysis6 Conclusion
Funder
Deutsche Forschungsgemeinschaft
Subject
Organic Chemistry,Catalysis
Cited by
11 articles.
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