Affiliation:
1. Department of Cardiovascular Medicine, The First People’s
Hospital of Yibin City, Yibin, China
Abstract
AbstractThe triglyceride-glucose (TyG) index, a recently proposed indicator for insulin
resistance, has been related with cardiovascular risks. We aimed to summarize
the association between TyG index and incidence of major adverse cardiovascular
events (MACEs) in patients with acute coronary syndrome (ACS). Cohort studies
demonstrating the association between TyG index and incidence of MACEs in ACS
patients with multivariate adjusted analyses were identified by search of
PubMed, Embase, and Web of Science databases. A random-effekt model
incorporating the heterogeneity was applied to pool the results. Eight cohort
studies with 19 611 participants were included. Results showed that compared to
those with the lowest category of TyG index, ACS patients with the highest
category of TyG index were independently associated with higher risk of MACEs
[risk ratio (RR): 1.94, 95% confidence interval (CI): 1.47–2.56,
I2=85%, p <0.001). Subgroup analyses
showed consistent results in patients with ST-segment elevated myocardial
infarction or non-ST segment elevated ACS, in patients with or without diabetes,
and in patients after percutaneous coronary intervention. Results were
consistent in studies with TyG index analyzed as continuous variable (RR for per
standard deviation increment of TyG index: 1.59, 95% CI:
1.38–1.83, I2=24%, p <0.001). In
conclusion, higher TyG index may be independently associated with higher
incidence of MACEs in patients with ACS.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
7 articles.
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