1,3-Bifunctional Nucleophilic Allylation Reagents: Preparative Methods and Synthetic Applications

Abstract

Abstract1,3-Bifunctional nucleophilic allylation reagents play an important role in organic synthesis. In this short review, we summarize the methods for the preparation of 1,3-bifunctional reagents and their reactions with various electrophiles. Synthetic applications of these reagents in the context of complex molecule synthesis are also discussed.1 Introduction2 Reagent Synthesis2.1 Symmetrical Reagents2.2 Unsymmetrical Reagents2.2.1 Bis-silane and Silyl-stannane Reagents2.2.2 Bis-boron and Silyl-boron Reagents3 Synthetic Applications3.1 Allylation of Aldehydes3.2 Allylation of Ketones3.3 Allylation of Imines3.4 Allylation of Other Electrophiles with 1,3-Bifunctional Allylation Reagents4 Summary