Affiliation:
1. College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University
2. Research Institute of Petroleum Exploration and Development of Sinopec
Abstract
AbstractAlkenes are one of the most abundant raw feedstocks and are utilized to construct complex chemicals, whilst cross-coupling reactions using alkenes represents a powerful method toward valuable chemicals. In the past decade, cross-coupling reactions of simple alkenes by chelation-assisted alkenyl C–H functionalization has attracted significant attention due to its atom/step efficiency and excellent Z/E selectivity, proceeding by C–H exo-cyclometalation and endo-cyclometalation. In this account, we summarize transition-metal-catalyzed cross-coupling reactions between alkenes to generate 1,3-dienes via C–H alkenylation,1,4-dienes through C–H allylation, multisubstituted alkenes via hydroalkenylation, and heterocycles by way of tandem alkenyl C–H functionalization/annulation. Asymmetric alkenyl C–H alkenylation to prepare axially chiral aryl 1,3-dienes is also discussed.1 Introduction2 Alkenyl C–H Alkenylation2.1 By endo-Cyclometalation2.2 By exo-Cyclometalation3 Alkenyl C–H Allylation3.1 By endo-Cyclometalation3.2 By exo-Cyclometalation4 Alkenyl C–H Alkylation via Hydroalkenylation5 Cascade Reactions6 Conclusion
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Hangzhou Normal University
National Key R&D Program of China
Sinopec, China