Affiliation:
1. Animal Care Center; Department of Genetics, Xi’an Jiao Tong
University, Xi’an Shaanxi, China
2. Department of Chemistry, University of Kotli Azad Jammu &
Kashmir Pakistan, Kotli, AJK, Pakistan
Abstract
Abstract
Aim of study This study investigated whether pre-activated bone marrow
cells with sodium nitro prusside have effectiveness in the inhibition of
diabetic wound healing in diabetic rabbits. In diabetic skin disorders and
conditions involved redox state disturbances. The aim was to determine the
effect of two minimum dosages of sodium nitro prusside, and its’
potential with bone marrow cells for chronic wound healing in-vivo.
Methods Full-thickness skin dorsal wounds were created on diabetic
rabbits. The effects of two minimum concentrations of sodium nitro prusside
solution with bone marrow cells on wound healing were studied. The useful
combination of sodium nitro prusside with bone marrow cells on wound repair may
be attributed to its functional influences on inflammation, angiogenesis, cell
proliferation, matrix deposition, and remodeling.
Results The in-vivo experiments confirmed that pre-activated bone marrow
cells contributed to wound healing by alleviating oxidative stress, increasing
proliferation and migration, decreasing apoptosis. In histological results,
improved collagen deposition, enhanced re-epithelization, angiogenesis, and
decreased inflammatory infiltration were also detected in wound biopsies.
Conclusions For the treatment of chronic wounds, cell-based therapy was an
attractive approach. Bone marrow cells have a low ability to differentiate
various types of cells or late healing without pretreatment. So it was needed to
increase their potency of differentiation. The transplantation of pretreated
bone marrow cells with a prime quantity of sodium nitro prusside solution
improved chronic wound healing with a greater level of growth factors and a
minimum level of oxidative stress.
Subject
Drug Discovery,General Medicine
Cited by
1 articles.
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