Affiliation:
1. Institute for Experimental and Clinical Pharmacology and Toxicology,
Lübeck, University of Lübeck, Germany
Abstract
AbstractThyroid hormone (TH) regulation is important for development, energy homeostasis,
heart function, and bone formation. To control the effects of TH in target
organs, the hypothalamus-pituitary-thyroid (HPT) axis and the tissue-specific
availability of TH are highly regulated by negative feedback. To exert a central
feedback, TH must enter the brain via specific transport mechanisms and cross
the blood-brain barrier. Here, tanycytes, which are located in the ventral walls
of the 3rd ventricle in the mediobasal hypothalamus (MBH), function as
gatekeepers. Tanycytes are able to transport, sense, and modify the release of
hormones of the HPT axis and are involved in feedback regulation. In this
review, we focus on the relevance of tanycytes in thyrotropin-releasing hormone
(TRH) release and review available genetic tools to investigate the
physiological functions of these cells.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
4 articles.
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