The Aryne Ene Reaction

Abstract

AbstractIntermolecular aryne ene reactions present opportunities to arylate a wide range of unsaturated substrates in a single step, whilst intramolecular reactions provide expedient access to valuable benzofused carbo- and heterocyclic frameworks. This short review will chart the development of the aryne ene reaction from initial reports that rationalise unexpected byproduct formation in competing [4+2] and [2+2] cycloadditions through to its exploitation in contemporary synthetic methodology.1 Introduction2 Alkene Ene Reactions2.1 Intermolecular2.2 Intramolecular3 Alkyne Ene Reactions3.1 Intermolecular3.2 Intramolecular4 Allene Ene Reactions5 Aromatic Ene Reactions6 Hetero Ene Reactions6.1 Enols6.2 Enamines6.3 Imines7 Conclusions