Affiliation:
1. The Second Department of General Surgery, Gansu Provincial Maternity
and Child-care Hospital, Lanzhou, China
2. Intensive Care Unit, Lanzhou University First Hospital, Lanzhou,
China
Abstract
AbstractMalnutrition is a risk factor of adverse clinical outcome in patients with
cancer. Recent studies suggest that geriatric nutritional risk index (GNRI)
could reflect the nutritional status in patients with various clinical
conditions. The aim of the systematic review and meta-analysis was to evaluate
the association between GNRI and survival of patients with hepatocellular
carcinoma (HCC). Observational studies evaluating the association between
pretreatment GNRI and survival of patients with HCC were obtained by search of
PubMed, Web of Science, Embase, Wanfang, and CNKI databases. A random-effects
model was used to pool the results after incorporating the potential influence
of heterogeneity. Seven cohort studies including 2636 patients with HCC
contributed to the meta-analysis. Pooled results showed that HCC patients with
low pretreatment GNRI were associated with poor overall survival [hazard ratio
(HR): 1.77, 95% confidence interval (CI): 1.32 to 2.37, p<0.001;
I2=66%) and progression-free survival (HR: 1.62, 95% CI:
1.39 to 1.89, p<0.001; I2=0%) as compared to those with
normal GNRI. Sensitivity analyses by excluding one study at a time showed
similar results (p all<0.05). Subgroup analyses showed that the
association between low pretreatment GNRI and poor survival of patients with HCC
was not significantly affected by age of the patients, main treatment, cutoff of
GNRI, or the follow-up durations. In conclusion, malnutrition indicated by a low
pretreatment GNRI may be a risk factor of poor survival of patients with
HCC.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
1 articles.
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