α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense-Reference-Cited by-同舟云学术

α-Glucosidase Inhibitory Depsidones from the Lichen Parmotrema tsavoense

Published:2020-05-29 Issue:11 Volume:86 Page:776-781
ISSN:0032-0943
Container-title:Planta Medica
language:en
Short-container-title:Planta Med

Author:

Duong Thuc-Huy¹²,Hang Tai-Xuan-Hoa³,Pogam Pierre Le⁴,Tran Thanh-Nha³,Mac Dinh-Hung⁵,Dinh Minh-Hiep⁶,Sichaem Jirapast⁷

Affiliation:

1. Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam

2. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam

3. Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam

4. Équipe “Pharmacognosie-Chimie des Substances Naturelles”, BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, Châtenay-Malabry, France

5. Department of Organic Chemistry, University of Science, Vietnam National University, Ha Noi, Vietnam

6. Management Board of Agricultural Hi-Tech Park, Ho Chi Minh City, Vietnam

7. Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand

Abstract

AbstractChemical investigation of the lichen Parmotrema tsavoense led to the isolation of 5 new depsidones, parmosidones F – J (1 – 5). These compounds were structurally elucidated using spectroscopic methods including HRESIMS and 2D NMR data. Compounds 1, 3, and 4 were evaluated for their inhibition of α-glucosidase. All exhibited potent α-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 17.6 µM, which was much lower than that of the positive control acarbose (IC50 449 µM).

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1179-1050.pdf

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