Affiliation:
1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University
2. Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, Hubei Engineering University
Abstract
AbstractA branch-selective hydroalkylation of alkoxyallenes with monofluorinated nucleophiles was developed using palladium catalysis, allowing construction of valuable α-monofluoroalkylated allylic ethers. Notably, this represents the first catalytic hydrofluoroalkylation of alkoxyallenes. The practicability of this method is highlighted by its broad substrate scope and diversified product elaborations. Initial investigation of the asymmetric variant could afford chiral fluorine-containing allylic ethers with up to 68% ee.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Science and Technology Innovation Plan Of Shanghai Science and Technology Commission
Fundamental Research Funds for the Central Universities
East China Normal University
Subject
Organic Chemistry,Catalysis
Cited by
1 articles.
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