Barringtogenol C-type Triterpenoid Saponins from the Stem Bark of Norway Maple (Acer Platanoides)

Author:

Xu Wen1,Zhang Lu23,Omar Raed2,Liu Wei1,Wei Zhengxi2,Zhang Zengguang1,Mu Yu1,Seeram Navindra P.2,Huang Xueshi1,Ma Hang24,Li Liya1

Affiliation:

1. Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, P. R. China

2. Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI, USA

3. College of Life Science, Jiangxi Normal University, Nanchang, P. R. China

4. School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, P. R. China

Abstract

AbstractFour new barringtogenol C-type triterpenoid saponins, namely acerplatanosides A – D (1–4), along with 22 known compounds (5–26), were isolated from the stem bark of Norway maple (Acer platanoides). Their structures were elucidated on the basis of comprehensive spectroscopic analyses and chemical hydrolysis. This is the first report of triterpenoid saponins isolated from Norway maple. Compounds 1, 3, and 4 showed cytotoxicity against 4 human cancer cell lines with IC50 values ranging from 9.4 to 39.5 µM.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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