Obesity and COVID-19: What are the Consequences?

Author:

Steenblock Charlotte1ORCID,Hassanein Mohamed2,Khan Emran G.3,Yaman Mohamad4,Kamel Margrit5,Barbir Mahmoud6,Lorke Dietrich E.7,Everett Dean8,Bejtullah Saqipi9,Lohmann Tobias10,Lindner Uwe11,Tahirukaj Ermal1,Jirjees Feras Jassim12,Soliman Sameh S.M.12,Quitter Friederike13ORCID,Bornstein Stefan R.114

Affiliation:

1. Department of Medicine III, Universitätsklinikum Carl Gustav Carus, Dresden, Germany

2. Department of Diabetes and Endocrinology, Dubai Hospital, Dubai, United Arab Emirates

3. Endocrinology and Diabetology, King’s College Hospital London, Dubai, United Arab Emirates

4. Building 6, Nesmah Technology, Dubai, United Arab Emirates

5. Center for Regenerative Therapies Dresden, Technische Universitat Dresden, Dresden, Germany

6. Department of Cardiology, Harefield Hospital, Harefield, United Kingdom of Great Britain and Northern Ireland

7. Department of Anatomy and Cellular Biology, Khalifa University, Abu Dhabi, United Arab Emirates

8. Department of Pathology and Infectious Diseases, Khalifa University, Abu Dhabi, United Arab Emirates

9. Research Unit, College Heimerer, Prishtina, Republic of Kosovo

10. MK5, Städtisches Klinikum Dresden, Dresden, Germany

11. Internal Medicine II, Klinikum Chemnitz, Chemnitz, Germany

12. College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates

13. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Dresden, Germany

14. School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK

Abstract

AbstractObesity is an increasing health problem all over the world. In combination with the current COVID-19 pandemic, this has turned into a massive challenge as individuals with overweight and obesity at all ages show a significant increase in their risk of getting severe COVID-19. Around 20% of all patients that were hospitalized for COVID-19 suffered from obesity alone, whereas obesity in combination with other metabolic comorbidities, such as type 2 diabetes and hypertension, account for up to 60% of all hospitalizations in relation to COVID-19. Therefore, it is of immense importance to put the spotlight on the high incidence of obesity present already in childhood both by changing the individual minds and by encouraging politicians and the whole society to commence preventive interventions for achieving a better nutrition for all social classes all over the world. In the current review, we aim to explain the different pathways and mechanisms that are responsible for the increased risk of severe COVID-19 in people with overweight and obesity. Furthermore, we discuss how the pandemic has led to weight gains in many people during lockdown. At the end, we discuss the importance of preventing such an interface between a non-communicable disease like obesity and a communicable disease like COVID-19 in the future.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Georg Thieme Verlag KG

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism

Reference90 articles.

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