Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp3)–H Amidation for the Synthesis of Isoindolinones

Abstract

AbstractThe synthesis of N-unprotected isoindolinones via rhodium(III)-catalyzed intramolecular C(sp3)–H amidation of various 2-methyl-N-substituted benzamides is developed. This protocol employs a free amino acid l-alanine as a ligand, which could significantly increase the reactivity of rhodium catalyst.