Reproductive Outcomes in Cases of Subclinical Hypothyroidism and Thyroid Autoimmunity: A Narrative Review

Author:

Carvalho Bruno Ramalho de1ORCID,Nácul Andrea Prestes2ORCID,Benetti-Pinto Cristina Laguna3ORCID,Rosa-e-Silva Ana Carolina Japur de Sá4ORCID,Soares Júnior José Maria5ORCID,Maciel Gustavo Arantes Rosa5ORCID,Baracat Edmund Chada5ORCID

Affiliation:

1. Hospital Sírio-Libanês, Brasília, Distrito Federal, Brazil

2. Human Reproduction Unit, Hospital Fêmina, Grupo Hospitalar Conceição, Porto Alegre, Rio Grande do Sul, Brazil

3. Department of Obstetrics and Gynecology, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil

4. Departamento of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

5. Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas - HCFMUSP, Faculdade de Medina da Universidade de São Paulo, São Paulo, SP, Brazil

Abstract

AbstractThyroid diseases are relatively common in women in the reproductive period. It is currently understood that clinically-evident thyroid disorders may impair ovulation and, consequently, fertility. However, to date it has not been proven that high serum levels of thyroid-stimulating hormone and/or positivity for antithyroid antibodies are associated to a reduction in fertility, mainly in the absence of altered thyroxine levels. The present comprehensive review aims to present current data on the association between subclinical hypothyroidism and/or thyroid autoimmunity and reproductive outcomes.

Publisher

Georg Thieme Verlag KG

Subject

Obstetrics and Gynaecology

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