Affiliation:
1. Ludwig-Maximilians-Universität München, Department Chemie
2. Colegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco
Abstract
AbstractA halogen–lithium exchange reaction of (hetero)aromatic halides performed in the presence of various electrophiles such as aldehydes, ketones, Weinreb amides, and imines using BuLi as exchange reagent and a commercially available flow set-up is reported. The organolithiums generated in situ were instantaneously trapped with various electrophiles (Barbier conditions) resulting in the formation of polyfunctional (hetero)arenes. This method enables the functionalization of (hetero)arenes containing highly sensitive functional groups such as esters, which are not tolerated in batch conditions.
Funder
Fundação de Amparo à Pesquisa do Estado de São Paulo
Studienstiftung des Deutschen Volkes
Deutsche Forschungsgemeinschaft
Ludwig-Maximilians-Universität München
Subject
Organic Chemistry,Catalysis
Cited by
10 articles.
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