t BuO2H/Cu(acac)2-Mediated Intramolecular Oxidative Lactonization of o-Allyl Arylaldehydes: Synthesis of 1-Oxoisochromans-Reference-Cited by-同舟云学术

t BuO2H/Cu(acac)2-Mediated Intramolecular Oxidative Lactonization of o-Allyl Arylaldehydes: Synthesis of 1-Oxoisochromans

Published:2020-09-29 Issue:03 Volume:53 Page:527-537
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Chang Meng-Yang¹²^ORCID,Lai Kai-Xiang¹,Chen Kuan-Ting¹

Affiliation:

1. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University

2. Department of Medical Research, Kaohsiung Medical University Hospital

Abstract

AbstractA concise route for the t BuO2H/Cu(acac)2-mediated synthesis of 1-oxoisochromans is described. This includes: (i) oxidation of oxygenated o-allyl arylaldehydes and (ii) sequential intramolecular lactonization of the resulting olefin-containing benzoic acids. A plausible mechanism is proposed and discussed.

Funder

Ministry of Science and Technology of the Republic of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1706469.pdf

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