Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C

Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C–N Bond Cleavage

Published:2021-10-14 Issue:03 Volume:54 Page:705-710
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Zeng Zhuo¹²,He Zhanyu¹,Yan Chu¹,Zhang Mei¹,Irfan Majeed¹,Wang Zijia¹

Affiliation:

1. School of Chemistry, South China Normal University

2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry

Abstract

AbstractPalladium-catalyzed Hiyama coupling of active thioureas via selective C–N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF2 as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.

Funder

Science and Technology Planning Project of Guangdong Province

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1720907.pdf

Reference19 articles.

1. Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

2. A Cross-Coupling Approach to Amide Bond Formation from Esters