Silver-Catalyzed, One-Pot, Three-Component Difunctionalization of Quinones: Synthesis of Indole-Functionalized p-Iminoquinone Derivatives

Abstract

AbstractA one-pot, three-component difunctionalization of quinones with indoles and arylamines has been developed to synthesize indole functionalized p-iminoquinones derivatives. The approach employed AgOAc as the catalyst in the presence of 3-chlorophenylboronic acid, giving a series of indole functionalized p-iminoquinones derivatives in moderate to good yields. This catalytic approach represents a step-economic and convenient strategy for the difunctionalization of quinones. A plausible reaction pathway has been proposed based on a series of control experiments.