Affiliation:
1. Piramal Discovery Solutions, Pharmaceutical Special Economic Zone
2. Department of Chemistry, Faculty of Science, The Madhav University
Abstract
AbstractUnder thermal conditions, 1,4,2-dioxazol-5-ones are known to undergo decarboxylation followed by Lossen’s rearrangement to yield isocyanates. Described herein is the in situ trapping of the resulting isocyanates with carbon nucleophiles to synthesize β-keto amides. Furthermore, a general and mild method for the conversion of the resulting β-keto amides into quinolin-2-ones is reported.
Funder
Piramal Pharma Solutions, India.
Cited by
2 articles.
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