Affiliation:
1. Laboratory of Pharmaceutical Chemistry, Kyoto Pharmaceutical University
Abstract
AbstractThe cross-dehydrogenative coupling between isochromans and nucleophiles using an electronically tuned nitroxyl radical catalyst, which effectively promotes the oxidation of benzylic ethers, has been investigated. Using sulfonamides as a nucleophile, modification of isochromans via oxidative C–N bond formation has been achieved at ambient temperature.
Funder
Ministry of Education, Culture, Sports, Science and Technology, Japan