Affiliation:
1. Institute of Drug Discovery Technology, Ningbo University
2. The State Key Laboratory of Chemical Oncogenomics, Shenzhen Graduate School of Peking University
Abstract
AbstractAn efficient, one-pot, three-component [3+2] cycloaddition reaction of azomethine ylide obtained from α-dicarbonyl compounds (cyclic and acyclic diketone or keto ester) and amino acids with maleimides under catalyst-free conditions has been developed. This cascade protocol shows high efficiency and remarkable functional group tolerance, and the ubiquitous succinimide-fused pyrrolizidines with a highly compact and strained scaffold were obtained with high yield and excellent diastereoselectivity. Furthermore, this novel and atom-economical strategy could be performed on a gram scale with comparable reaction efficiency.
Funder
Science and Technology Planning Project of Guangdong Province
Natural Science Foundation of Zhejiang Province
National Natural Science Foundation of China
Subject
Organic Chemistry,Catalysis
Cited by
11 articles.
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