Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia-Reference-Cited by-同舟云学术

Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia

Published:2020-06-19 Issue:08 Volume:42 Page:460-467
ISSN:0100-7203
Container-title:Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics
language:en
Short-container-title:Rev Bras Ginecol Obstet

Author:

Sandrim Valeria Cristina¹^ORCID,Luizon Marcelo Rizzatti²^ORCID,Pilan Eliane¹^ORCID,Caldeira-Dias Mayara¹^ORCID,Coeli-Lacchini Fernanda Borchers³^ORCID,Kors Georgia¹^ORCID,Berndt Iuly¹^ORCID,Lacchini Riccardo⁴^ORCID,Cavalli Ricardo Carvalho⁵^ORCID

Affiliation:

1. Department of Pharmacology, Instituto de Biociências de Botucatu da Universidade Estadual Paulista, Botucatu, SP, Brazil

2. Department of Genetics, Ecology and Evolution, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

3. Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, São Paulo, SP, Brazil

4. Department of Psychiatric Nursing and Human Sciences, Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil

5. Department of Gynecology and Obstetrics, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil

Abstract

Abstract Objective We examined the interaction of polymorphisms in the genes heme oxygenase-1 (HMOX1) and nitric oxide synthase (NOS3) in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy. Methods The genes HMOX1 (rs2071746, A/T) and NOS3 (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 (HO-1) were measured using enzyme-linked immunosorbent assay (ELISA). Results We found interactions between genotypes of the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA. Conclusion We found interactions between the HMOX-1 and NOS3 genes and responsiveness to methyldopa and that the HMOX1 polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.

Publisher

Georg Thieme Verlag KG

Subject

Obstetrics and Gynecology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1712484.pdf

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