Diastereoselective Synthesis of Pyrazolines by Metal-Free Rearrangement of Bicyclic Triazolines-Reference-Cited by-同舟云学术

Diastereoselective Synthesis of Pyrazolines by Metal-Free Rearrangement of Bicyclic Triazolines

Published:2020-07-09 Issue:19 Volume:52 Page:2892-2898
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Pellegrino Sara¹,Erba Emanuela¹,Bucci Raffaella,Clerici Francesca

Affiliation:

1. DISFARM-Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano

Abstract

The metal-free preparation of diazoalkanes through the ring rearrangement of bicyclic triazolines is reported here. Their use in 1,3-dipolar cycloaddition reactions with electron-withdrawing alkenes was investigated. This synthetic procedure allows differently substituted pyrazolines to be obtained in few steps and with high atom economy.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1707173.pdf

Reference10 articles.

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4. Silver-Catalyzed [2+1] Cyclopropenation of Alkynes with Unstable Diazoalkanes:N-Nosylhydrazones as Room-Temperature Decomposable Diazo Surrogates

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