Diagnosis and Treatment of Trauma-Induced Coagulopathy by Viscoelastography

Author:

Hartmann Jan1,Walsh Mark234,Grisoli Anne5,Thomas Anthony V.23,Shariff Faisal5,McCauley Ross5,Vande Lune Stefani5,Zackariya Nuha23,Patel Shivani23,Farrell Michael S.6,Sixta Sherry6,March Robert2,Evans Edward2,Tracy Rebecca7,Campello Elena8,Scărlătescu Ecaterina9,Agostini Vanessa10,Dias João11,Greve Sarah1,Thomas Scott34

Affiliation:

1. Haemonetics Corporation, Boston, Massachusetts

2. Saint Joseph Regional Medical Center, Mishawaka, Indiana

3. Memorial Hospital Trauma Center, South Bend, Indiana

4. W. M. Keck Center for Transgene Research, University of Notre Dame, Notre Dame, Indiana

5. Indiana University School of Medicine—South Bend Campus, Notre Dame, Indiana

6. Department of Trauma, Surgery, and Critical Care Medicine, Christiana Care Health Services, Wilmington, Delaware

7. Department of Emergency Medicine, Southern Illinois University School of Medicine, Springfield, Illinois

8. Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine, Padua University Hospital, Padua, Italy

9. Department of Anaesthesia and Intensive Care, Fundeni Clinical Institute, Bucharest, Romania

10. Department of Clinical Pathology, Transfusion Medicine Cesena/Forlì and Blood Establishment, Azienda USL della Romagna, Romagna, Italy

11. Haemonetics S. A., Signy, Switzerland

Abstract

AbstractThis article explores the application of viscoelastic tests (VETs) in trauma-induced coagulopathy and trauma resuscitation. We describe the advantages of VETs over conventional coagulation tests in the trauma setting and refer to previous disciplines in which VET use has reduced blood product utilization, guided prohemostatic agents, and improved clinical outcomes such as the mortality of critically bleeding patients. We describe different VETs and provide guidance for blood component therapy and prohemostatic therapy based on specific VET parameters. Because the two most commonly used VET systems, rotational thromboelastometry and thromboelastography, use different activators and have different terminologies, this practical narrative review will directly compare and contrast these two VETs to help the clinician easily interpret either and use the interpretation to determine hemostatic integrity in the bleeding trauma patient. Finally, we anticipate the future of new viscoelastic technologies that can be used in this setting.

Publisher

Georg Thieme Verlag KG

Subject

Cardiology and Cardiovascular Medicine,Hematology

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