Erythrocyte Complement Receptor 1 (ECR1) Gene Polymorphisms and Neonatal Respiratory Distress Syndrome-Reference-Cited by-同舟云学术

Erythrocyte Complement Receptor 1 (ECR1) Gene Polymorphisms and Neonatal Respiratory Distress Syndrome

Published:2020-10-05 Issue: Volume: Page:
ISSN:2146-4596
Container-title:Journal of Pediatric Genetics
language:en
Short-container-title:J Pediatr Genet

Author:

Rabie Walaa¹,Al-Taweel Ahmed¹,Abuelhamd Walaa A.²,Shahin Walaa²,Nazeer Marian¹,Aly Hany³^ORCID

Affiliation:

1. Department of Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

2. Department of Pediatrics, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt

3. Department of Neonatology, Cleveland Clinic Children's, Cleveland, Ohio, United States

Abstract

AbstractTo evaluate the role of erythrocyte complement receptor 1 (ECR1) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of the alleles (HindIII) were performed. Allele L of HindIII restricted single nucleotide polymorphism (SNP) associated with the severity of RDS. Duration of oxygen and ventilation in genotypes AA and AG of A3650G SNP was longer than genotype GG (17.6 ± 19.4 and 8.6 ± 4.5 days, p = 0.01) and (8.9 ± 11.9 and 3.9 ± 3.53 days, p = 0.03), respectively. A3650G and HINDIII digested gene polymorphisms of ECR1 may be of little importance for RDS.

Publisher

Georg Thieme Verlag KG

Subject

Genetics(clinical),Pediatrics, Perinatology, and Child Health

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1717108.pdf

Reference19 articles.

1. Respiratory distress in the newborn;C L Hermansen;Am Fam Physician,2007

2. Treatment patterns and clinical outcomes in neonates diagnosed with respiratory distress syndrome in a low-income country: a report from Bangladesh;R M Hubbard;Anesth Analg,2018

3. Complement and bacterial infections: from molecular mechanisms to therapeutic applications;D AC Heesterbeek;J Innate Immun,2018

4. Leucocyte complement receptor 1 (CR1/CD35) transcript and its correlation with the clinical disease activity in rheumatoid arthritis patients;D Anand;Clin Exp Immunol,2014

5. Bedside selection of positive end-expiratory pressure in mild, moderate, and severe acute respiratory distress syndrome;D Chiumello;Crit Care Med,2014