Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis-Reference-Cited by-同舟云学术

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Published:2020-04 Issue:04 Volume:120 Page:538-564
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

d’Alessandro Elisa¹,Becker Christian²,Bergmeier Wolfgang³,Bode Christoph⁴,Bourne Joshua H.⁵,Brown Helena⁶,Buller Harry R.⁷,ten Cate-Hoek Arina J.¹,ten Cate Vincent⁸,van Cauteren Yvonne J. M.⁹,Cheung Yam F. H.¹⁰,Cleuren Audrey¹¹,Coenen Danielle¹²,Crijns Harry J. G. M.⁹,de Simone Ilaria¹²,Dolleman Sophie C.¹³,Klein Christine Espinola¹⁴,Fernandez Delia I.¹²,Granneman Lianne¹⁵,van t Hof Arnoud⁹,Henke Peter¹⁶,Henskens Yvonne M. C.¹⁷,Huang Jingnan¹²,Jennings Lisa K.¹⁸,Jooss Natalie¹²,Karel Mieke¹²,van den Kerkhof Danique¹²,Klok Frederik A.¹⁹,Kremers Bram¹,Lämmle Bernhard²⁰,Leader Avi¹²¹,Lundstrom Annika²²,Mackman Nigel²³,Mannucci Pier M.²⁴,Maqsood Zahra⁶,van der Meijden Paola E. J.¹¹²,van Moorsel Marc¹⁵,Moran Luis A.²⁵,Morser John²⁶,van Mourik Manouk⁹,Navarro Stefano⁶,Neagoe Raluca A. I.⁵,Olie Renske H.¹,van Paridon Pauline¹,Posma Jens¹,Provenzale Isabella¹²,Reitsma Pieter H.¹³,Scaf Billy¹,Schurgers Leon¹²,Seelig Jaap¹²⁷,Siegbahn Agneta²⁸,Siegerink Bob²⁹,Soehnlein Oliver³⁰,Soriano Eva Maria³¹,Sowa Marcin A.³¹,Spronk Henri M. H.¹,Storey Robert F.³²,Tantiwong Chukiat¹²,Veninga Alicia¹²,Wang Xueqing⁵,Watson Steve P.⁵,Weitz Jeff³³,Zeerleder Sacha S.³⁴,ten Cate Hugo¹,

Affiliation:

1. Laboratory for Clinical Thrombosis and Hemostasis, Department of Biochemistry and Internal Medicine and Thrombosis Expert Center, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands

2. Department of Dermatology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany

3. Department of Biochemistry and Biophysics, McAllister Heart Institute, University of North Carolina, Chapel Hill, United States

4. Department of Cardiology and Angiology I, Medical Center - University of Freiburg, University Heart Center Freiburg, Bad Krozingen, Germany

5. Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

6. Rudolf-Virchov-Zentrum, DFG Forschungszentrum fur Experimentelle Biomedizin, Wurzburg, Germany

7. Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands

8. Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

9. Department of Cardiology, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands

10. Leibniz-Institut für Analytische Wissenschaften – ISAS, Dortmund, Germany

11. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States

12. Department of Biochemistry, Maastricht University and CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands

13. Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Experimental Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands

14. Center of Cardiology/Cardiology I, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

15. Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands

16. Michigan Medicine Vascular Surgery Clinic, Cardiovascular Center, Ann Arbor, Michigan, United States

17. Central Diagnostic Laboratory, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands

18. CirQuest Labs, LLC and the University of Tennessee Health Science Center, Memphis, Tennessee, United States

19. Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands

20. Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Haemostasis Research Unit, University College London, London, United Kingdom

21. Department of Hematology, Rabin Medical Center, Petah Tikva, Israel

22. Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden

23. Department of Medicine, UNC McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, United States

24. Scientific Direction, IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation, Milano, Italy

25. CiMUS, University of Santiago de Compostela, Santiago de Compostela, Spain

26. Division of Hematology, Stanford University School of Medicine and Palo Alto Veterans Administration Health Care System, California, United States

27. Department of Cardiology, Rijnstate ziekenhuis, Arnhem, The Netherlands

28. Department of Medical Sciences, Clinical Chemistry and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

29. Center for Stroke research Berlin, Charité Universitätamedizin, Berlin, Germany

30. Institute for Cardiovascular Prevention, Ludwig Maximilian University Munich, Munich, Germany

31. Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom

32. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

33. Division of Hematology and Thromboembolism, Department of Medicine and Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada

34. Department of Haematology and Central Haematology Laboratory, Inselspital, Bern University Hospital, University of Bern, and Department for BioMedical Research, University of Bern, Bern, Switzerland

Abstract

AbstractThrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

Funder

European Union's Horizon 2020 research and innovation program

Netherlands Heart Foundation

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1708035.pdf

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