Metastatic Biphasic Primitive Tumor in the Mandible of a Child

Author:

Pinheiro Tiago Novaes1,Leite Milena Gomes Melo1,Bindá Fábio Arruda2,Dutra André Luiz Tannus3,Sarmento Naelka3,Cabral Lioney Nobre4,Consolaro Alberto5,Bacchi Carlos Eduardo6

Affiliation:

1. Department of Oral Pathology and Oral Medicine, Surgical Pathology and Oral and Maxillofacial Pathology Service, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil

2. Department of Head and Neck Oncology, Fundação Centro de Controle de Oncologia do Estado do Amazonas, Planalto, Manaus-AM, Brazil

3. Department of Pediatric Dentistry, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil

4. Department of Oral Pathology and Oral Medicine, Amazonas State University, Cachoeirinha, Manaus-AM, Brazil

5. Department of Oral Pathology, Bauru School of Dentistry, University of São Paulo, Bauru-SP, Brazil

6. Department of Pathology, Laboratório Bacchi Ltd., LB, Botucatu-SP, Brazil

Abstract

AbstractPediatric mandibular tumors present an aggressive biological behavior and difficult diagnosis. A wide range of odontogenic and nonodontogenic tumors comprise the spectrum of these lesions. We report a case of a 1-year-old male child patient showing facial asymmetry symptomatic of an expansive lesion extending throughout the body and ramus of the left hemimandible with a diameter of 8 cm. The histopathological report suggested a high-grade mucoepidermoid carcinoma (MEC), recommending further immunohistochemical investigation of the ectomesenchymal or neuroectodermal origin of the tumor cells. The patient evolved with extensive bilateral pleural effusion followed by metastasis in the middle third of the right humerus, and died 2 months after the first biopsy procedure by acute renal failure with tubular necrosis, before a final inconclusive immunohistochemical report was reached. The lack of resources for less-favored regions of Brazil impairs rapid biomolecular examinations such as immunohistochemical resulting in delay of appropriate therapeutic procedures.

Publisher

Georg Thieme Verlag KG

Subject

General Dentistry

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