Pentamethylphenyl (Ph*) and Related Derivatives as Useful Acyl Protecting Groups for Organic Synthesis: A Preliminary Study

Author:

Donohoe Timothy J.1,Cheong Choon Boon,Frost James R.

Affiliation:

1. Department of Chemistry, University of Oxford, Chemical Research Laboratory

Abstract

AbstractA study of acyl protecting groups derived from the Ph* motif is reported. While initial studies indicated that a variety of functional groups were not compatible with the Br2-mediated cleavage conditions required to release the Ph* group, strategies involving the use of different reagents or a modification of Ph* itself (Ph*OH) were investigated to solve this problem.

Funder

Agency for Science, Technology and Research

Engineering and Physical Sciences Research Council

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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