Affiliation:
1. Chemistry Department, Taras Shevchenko National University of Kyiv
2. Enamine Ltd.
3. Division of Functional Materials Chemistry, SSI ‘Institute for Single Crystals’, National Academy of Sciences of Ukraine
Abstract
Synthetic approach to fused azasultams with 1,2,4-thiadiazepine framework via base promoted protocols has been developed. 1H-Azole-2-carboxylates and N-(chloromethyl)-N-methylmethanesulfonamide were used as ambiphilic building blocks in the one-pot and two-step reaction sequences. Chemical behavior of the obtained azasultams in reactions with amines, hydrazine, DMFDMA, and NaBH4 was investigated. An enamino ketone derived from an azasultam was exploited in the synthesis of new pyrazole and pyrimidine heterocycles.
Funder
Ministry of Education and Science of Ukraine
Subject
Organic Chemistry,Catalysis
Cited by
9 articles.
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