Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism-Reference-Cited by-同舟云学术

Methylenetetrahydrofolate Reductase (MTHFR) C677T and A1298C Polymorphisms in Georgian Females with Hypothyroidism

Published:2020-07-20 Issue:02 Volume:07 Page:047-050
ISSN:2699-9404
Container-title:Global Medical Genetics
language:en
Short-container-title:Global Medical Genetics

Author:

Kvaratskhelia Tamar¹²,Abzianidze Elene¹,Asatiani Ketevan³,Kvintradze Merab¹,Surmava Sandro¹,Kvaratskhelia Eka¹

Affiliation:

1. Department of Molecular and Medical Genetics, Tbilisi State Medical University, Tbilisi, Georgia

2. Division of Endoctinology, Medical Center “Medimedi,” Tbilisi, Georgia

3. Metabolic Disorders, National Institute of Endocrinology, Tbilisi, Georgia

Abstract

AbstractThe aim of this study was to investigate the frequency of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in Georgian females with hypothyroidism. Thirty-four patients and 29 healthy individuals were recruited in this study. Polymerase chain reaction-restriction fragment length polymorphism analyses were used for genotyping of MTHFR polymorphisms. The results of this study suggest that the MTHFR C677T variant was significantly associated with hypothyroidism. In addition, in individuals with T allele risk of hypothyroidism significantly increased. Combination of CT/AA genotypes was more prevalent in the hypothyroid patients than in the control group. Thus, C677T polymorphism could be a possible genetic factor contributing to the pathophysiology of hypothyroidism, possibly through hyperhomocysteinemia.

Publisher

Georg Thieme Verlag KG

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1714091.pdf

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