Zinc(II)-Catalyzed Synthesis of Secondary Amides from Ketones via Beckmann Rearrangement Using Hydroxylamine-O-sulfonic Acid in Aqueous Media-Reference-Cited by-同舟云学术

Zinc(II)-Catalyzed Synthesis of Secondary Amides from Ketones via Beckmann Rearrangement Using Hydroxylamine-O-sulfonic Acid in Aqueous Media

Published:2020-05-25 Issue:21 Volume:52 Page:3272-3276
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Jat Jawahar L.¹^ORCID,Verma Saumya¹,Kumar Puneet¹,Khatana Anil K.²,Chandra Dinesh¹^ORCID,Yadav Ajay K.¹,Tiwari Bhoopendra²^ORCID

Affiliation:

1. Department of Chemistry, Babasaheb Bhimrao Ambedkar University (A Central University)

2. Division of Molecular Synthesis & Drug Discovery, Centre of Biomedical Research, SGPGIMS-Campus

Abstract

A zinc(II)-catalyzed single-step protocol for the Beckmann rearrangement using hydroxylamine-O-sulfonic acid (HOSA) as the nitrogen source in water was developed. This direct method efficiently produces secondary amides under open atmosphere in a pure form after basic aqueous workup. It is environmentally benign and operationally simple.

Funder

Science and Engineering Research Board

University Grants Commission

Council of Scientific and Industrial Research

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1707809.pdf

Reference9 articles.

1. Cu(OTf)2-Catalyzed Beckmann Rearrangement of Ketones Using Hydroxylamine-O-sulfonic Acid (HOSA)