Quinolin-8-yl Formate: A New Option for Small-Scale Carbonylation Reactions in Microwave Reactors-Reference-Cited by-同舟云学术

Quinolin-8-yl Formate: A New Option for Small-Scale Carbonylation Reactions in Microwave Reactors

Published:2020-07-17 Issue:16 Volume:31 Page:1608-1612
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Ruble J. Craig¹^ORCID,Maddocks Christopher J.²,Aathimanikandan Sivakumar V.³,Richardson Jeffery²^ORCID

Affiliation:

1. Discovery Chemistry Research and Technologies, Eli Lilly and Company

2. Discovery Chemistry Research and Technologies, Eli Lilly and Company Limited

3. Albany Molecular Research, Inc.

Abstract

A convenient procedure for conducting small-scale carbonylations of aryl or benzyl halides in a microwave reactor by using quinolin-8-yl formate is described. The resulting 8-acyloxyquinolines were shown to be more reactive than phenyl esters in acyl-transfer reactions, and their utility for the production of esters and amides was demonstrated.

Funder

Eli Lilly and Company

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1707187.pdf

Reference15 articles.

1. Palladium-catalyzed carboalkoxylation of aryl, benzyl, and vinylic halides

2. Palladium-catalyzed amidation of aryl, heterocyclic, and vinylic halides

3. Palladium-Catalyzed Carbonylation Reactions of Aryl Halides and Related Compounds

4. The Chemistry of CO: Carbonylation

5. Palladium-catalyzed esterification of aryl halides using aryl formates without the use of external carbon monoxide

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