Affiliation:
1. Department of Chemistry, Fort Lewis College
2. Department of Chemistry, Hamline University
Abstract
AbstractA synthetic approach to grandisol is described. The route to the cyclobutane core relies on an efficient intramolecular [2+2] cycloaddition that establishes the required cis-ring fusion at the adjacent side chains of the cyclobutane ring. Using a new two-step lithium/halide homologation procedure, norgrandisol was efficiently converted into grandisol. This new approach enables the synthesis of grandisol in five steps from commercially available starting material in 22% overall yield.
Funder
National Science Foundation
American Chemical Society Petroleum Research Fund
Frederick Gardner Cottrell Foundation
Howard Hughes Medical Institute
Subject
Organic Chemistry,Catalysis
Cited by
1 articles.
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