Total Synthesis of Resolvin T4

Author:

Ogawa Narihito1ORCID,Arai Kohei1,Kobayashi Yuichi2

Affiliation:

1. Department of Applied Chemistry, Meiji University

2. Organization for the Strategic Coordination of Research and Intellectual Properties, Meiji University

Abstract

AbstractA total synthesis of resolvin T4 was achieved by connecting three intermediates by Wittig reactions. The enal in the C1–C10 part was constructed through reduction of a propargylic alcohol with Red-Al followed by oxidation. The enal moiety in the C11–C16 part was synthesized by a ring-opening reaction of a silyl epoxide followed by a Peterson elimination. The chiral centers at C7 and C13 were constructed by ruthenium-catalyzed asymmetric transfer hydrogenation.

Funder

Meiji University

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Stereoselective Synthesis of Volicitin and 9-D 1-Volicitin;Synlett;2024-01-15

2. Total synthesis of resolvin D3;Organic & Biomolecular Chemistry;2022

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