The Art of Detecting Antibodies against Factor VIII-Reference-Cited by-同舟云学术

The Art of Detecting Antibodies against Factor VIII

Published:2020-09-22 Issue:04 Volume:40 Page:485-490
ISSN:0720-9355
Container-title:Hämostaseologie
language:de
Short-container-title:Hamostaseologie

Author:

Tiede Andreas¹,Alberio Lorenzo²

Affiliation:

1. Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany

2. Service et Laboratoire Central d'Hématologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Abstract

AbstractAntibodies against factor VIII (FVIII) can be detected based on their ability to neutralize the procoagulant activity of FVIII (neutralizing antibodies, inhibitors), or based on their specific binding capacity to FVIII protein. This article reviews the available assays and their clinical interpretation in patients with congenital and acquired hemophilia.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1223-3353.pdf

Reference27 articles.

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3. Improvements in factor VIII inhibitor detection: from Bethesda to Nijmegen;B Verbruggen;Semin Thromb Hemost,2009

4. The Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: improved specificity and reliability;B Verbruggen;Thromb Haemost,1995

5. Validation of 4% albumin as a diluent in the Bethesda assay for FVIII inhibitors;G W Kershaw;Thromb Res,2013

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