Affiliation:
1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University
of Dhaka, Dhaka, Bangladesh
2. Centre for Advanced Research in Sciences (CARS), University of Dhaka,
Dhaka, Bangladesh
Abstract
AbstractDrug interaction has turned into the preeminent regarding issues for a prescriber
during polypharmacy. The foremost objective of this research was to form a
complex between linagliptin and rabeprazole sodium by in vitro
interactions. The interactions between the drugs have been examined by
monitoring some chromatographic and spectroscopic analyses viz. TLC, HPLC,
FT-IR, UV, Job’s plot, conductometric titrations, and Ardon’s
spectrophotometric strategy. Rabeprazole sodium formed a stable complex with
linagliptin, which was ensured from the insight of these analytical data. The
developed complex’s bright spot was clearly watched in the TLC plate.
The retention time (Rt) of the formed complex was 5.303 min,
where the Rt were 3.364 and 3.103 min for linagliptin and
rabeprazole sodium, respectively, in HPLC chromatograms. In FT-IR and UV spectra
of the formed complex revealed some disappearance of characteristic peaks that
affirmed the complexation. All of the variations of the spectrophotometric and
chromatographic properties from the antecedent drugs indicated the drug-drug
interaction. Another crucial fact for the experimental aim was to affirm the
assumed drug interaction by in vivo model examination. The assessment of
anti-diabetic property on alloxan-induced Swiss albino mice proved significant
in vivo interaction between the drugs. It was outlined from the
animal study that the hypoglycemic activity of linagliptin might be
significantly affected due to the complex formation of the drug with a proton
pump inhibitor (PPI). Nonetheless, it is the primary outcome of the interaction,
which recommends the bigger in vivo study or clinical monitoring on the
human model.
Subject
Drug Discovery,General Medicine
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