Abstract
Summary1. The breakdown rate of ADP (200 µM/ml) by the platelet-poor plasma of the animals studied (human, rabbit, cat, sheep and rat) is consistent within a species and characteristic of that species.2. The breakdown rate of ADP is related directly to the B. M. R. of that species.3. The platelet aggregation response to ADP is extremely variable even within a species, and bears little, if any, relationship to ADP breakdown.4. The breakdown of ADP added to whole blood has been studied both in normal subjects and in patients with myocardial infarctions. The breakdown patterns were found to be identical.5. The ADP-ase activity of whole blood was localised almost entirely in the white cells.
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8 articles.
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1. Haemodynamic and Biochemical Interactions in Intravascular Platelet Aggregation;Ciba Foundation Symposium 71 - Blood Cells and Vessel Walls;2008-05-30
2. Similarities and differences between rabbit and human platelet characteristics and functions;Comparative Biochemistry and Physiology Part A: Physiology;1992-09
3. Platelets in Relation to Atherosclerosis;International Symposium State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models;1978
4. FLUID-MECHANICAL AND BIOCHEMICAL INTERACTIONS IN HAEMOSTASIS;British Medical Bulletin;1977-09
5. Effects of unphysiological blood flow on circulating cells;Physiological and Clinical Aspects of Oxygenator Design;1976