Comparison of Six Commercial Plasma References for Factor VIII, Factor IX and von Willebrand Factor

Author:

Kasper Carol K1,Aronson David L2,Davignon George3,Foster Paul4,Hillman-Wiseman Carol5,Lusher Jeanne M5,Manco-Johnson Marilyn6,Meade James B7,Montgomery Robert R4,Rickies Frederick R8,White Gilbert C7

Affiliation:

1. The Orthopaedic Hospital University of Southern California, Los Angeles, California, USA

2. The George Washington University Medical Center, Washington D.C., USA

3. The University of California, San Diego, California, USA

4. The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA

5. The Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan

6. The University of Colorado Health Sciences Center, Denver, Colorado,USA

7. The University of North Carolina Hospitals, Chapel Hill, North Carolina, USA

8. The University of Connecticut Health Center, Farmington, Connecticut, USA

Abstract

SummarySix brands of normal reference plasma produced in the United States, with assigned assay values for factor VIII and IX and, in four instances, ristocetin cofactor and von Willebrand antigen, were assayed in nine coagulation laboratories in academic institutions in the same country. Differences in mean assays of reference plasmas, as a percent of labelled potency, were significant and were greater than differences among laboratories. Standard methods of assigning potency to commercial reference plasmas are recommended.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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