Type I Congenital Plasminogen Deficiency Is not a Risk Factor for Thrombosis

Author:

Shigekiyo T1,Uno Y1,Tomonari A1,Satoh K2,Hondo H2,Ueda S2,Saito S1

Affiliation:

1. The First Department of Internal Medicine, The University of Tokushima, Tokushima, Japan

2. Department of Neurological Surgery, School of Medicine, The University of Tokushima, Tokushima, Japan

Abstract

SummaryThe risk of thrombosis in type I congenital plasminogen (PLG) deficiency has been suggested, but is still not confirmed. We studied 40 members of two unrelated families with this disease, and found that 21 were heterozygotes of type I congenital PLG deficiency. Three of them had thrombosis, but the other 18 had no thrombosis. The percentages of family members with no history of thrombosis up to a given age among subjects with type I congenital PLG deficiency and healthy controls were analyzed by the Kaplan-Meier method. No significant difference between the two groups was observed by the generalized Wilcoxon test (p = 0.23). These results suggest that there is no significant correlation between type I congenital PLG deficiency and thrombosis.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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