Purification of a Fibrinolysis Inhibitor in Serum from Post-Traumatic Patients

Author:

Bagge Lars1,Björk Ingemar1,Saldeen Tom1,Wallin Rolf1

Affiliation:

1. The Department of Forensic Medicine, University of Uppsala and Department of Medical and Physiological Chemistry, Royal Veterinary College, The Biomedical Centre, Uppsala, Sweden

Abstract

SummaryA fibrinolysis inhibitor was purified in serum from post-traumatic patients by the use of flat bed electrofocusing of serum desalted by gel chromatography followed by affinity chromatography on a column of matrix-linked plasminogen. Disc gel electrophoresis yielded one protein band. The inhibitor protein was also found in normal serum, but in a lower concentration.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Cited by 19 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. An ibuprofen-antagonized plasmin inhibitor released by human endothelial cells;Experimental and Molecular Pathology;1991-02

2. Literatur;Die klinische Wertigkeit biochemischer Faktoren beim Polytrauma;1991

3. Pulmonary microembolism: A cause of lung injury;Journal of Surgical Research;1987-10

4. Ibuprofen as an antagonist of inhibitors of fibrinolysis in wound fluid;Thrombosis Research;1987-01

5. Coagulation, fibrinolysis and bleeding after open-heart surgery;Scandinavian Journal of Thoracic and Cardiovascular Surgery;1986-01

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