Impact of Smoking, Physical Training and Weight Reduction on FVII, PAM and Hemostatic Markers in Sedentary Men

Author:

Gris Jean-Christophe1,Schved Jean-François1,Feugeas Olivier1,Aguilar-Martinez Patricia1,Arnaud Anne1,Sanchez Nicole1,Sarlat Christian1

Affiliation:

1. The Laboratoire d’Hématologie et Immunologie, Centre Hospitalier Gaston Doumergue, Nîmes, France

Abstract

SummaryThe variations of FVII, PAI-1, TAT complexes, fibrinopeptide A, D-Dimers and beta thromboglobulin plasma levels were studied on 30 sedentary men, smokers and non-smokers, who were admitted to a 6 months’ program of physical training and smoking cessation. After 3 months of intervention, sustained physical training was associated with the decrease of FVII and PAI-1 levels. Mild exercise performed during a second 3-month period could maintain normal FVII and PAI-1 activities but participants who stopped the training increased their FVII and PAI-1 plasma levels. FVII was not influenced by smoking habits. Smoking cessation seemed to slightly potentiate the decrease of PAI-1 levels associated with mild exercise. Overweight, FVII and PAI-1 levels were correlated and the weight reduction induced by training was related to the changes in the factors. In smokers, physical exercise was associated with a significant increase of hemostatic markers. This exercise-induced variation disappeared after 3 months of intervention in participants who stopped smoking and reappeared in those who smoked again after 6 months of intervention. This finding was not influenced by the physical training program.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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