Studies on Thrombolysis with Streptokinase

Abstract

SummaryThe patterns of fibrin and the contents of plasminogen, of α1 antitrypsin and of a2-macroglobulin were studied in whole blood clots before and after retraction and in arterial and venous thrombi of various age by an indirect immunofluorescent method.By reaction with antifibrinogen a network of fibrin fibers was displayed in the first week. The fibers were condensed to form trabecula in the first months. After several months the reaction with antifibrinogen was reduced or abolished even in non organized thrombi.In clots and thrombi the plasminogen content is lost during retraction, However, a considerable increase is observed in thrombi up to several months old.The plasma plasmin inhibitors are only partially expressed during retraction. Later a considerable increase may occur.The relevance of these findings for thrombolysis is discussed.