Affiliation:
1. Department of Neurology, University Hospital of Heidelberg, Heidelberg, Germany
2. Department of Neurology and Cancer Center, Massachusetts General Hospital, Boston, Massachusetts
Abstract
Neurofibromatosis 1, neurofibromatosis 2, and schwannomatosis are a group of related classically inherited but often times sporadic tumor suppressor syndromes. Neuro-oncologists should recognize these syndromes, initiate necessary tests in patients with a clinical suspicion, and support genetic counseling of patients and families. In this review, clinical presentation, diagnostic criteria, day-to-day management including supportive care as well as updates on genetics, and experimental treatment strategies are discussed.
Subject
Clinical Neurology,Neurology