Effect of Venous Occlusion on Coagulation and Fibrinolytic Components in Normal Subjects

Author:

Nilsson Inga Marie,Robertson B

Abstract

SummaryThe components of the coagulation and fibrinolytic systems were studied before and during venous occlusion for 20 min of the arm and of the leg in 30 healthy volunteers. For comparison total serum proteins, α2-macroglobulin and albumin were also determined. The values recorded after venous occlusion were corrected according to the changes in the haematocrit.The fibrinolytic activity induced by venous occlusion was markedly higher (4 to 6 times) in the arms than in the legs. In 2 of the subjects, however, venous occlusion was not followed by any increase of fibrinolysis.After venous occlusion total serum proteins increased by 15% but albumin only by 2%. The P & P, AHF, haemophilia B-factor and fibrinogen increased by 5-20%. The factor V-level remained unchanged. The AHF and factors XI and XII increased by about 20% in the legs but by about 40% in the arms. In other respects the upper and lower limbs showed the same type of coagulation changes.The plasminogen level increased in both arms and legs by 10%. The inhibitors of urokinase activation and the α2M remained unchanged, which means that these inhibitors compared with the increase in total serum proteins had decreased by about 10%.The 2 normals, in whom venous occlusion failed to produce any increase of fibrinolysis, had no signs of Hageman trait and after venous stasis the same coagulation changes occurred as in the individuals who developed high fibrinolytic activity.The findings argue against the Hageman factor playing an essential role in the activation of the fibrinolytic system during venous occlusion and indicate that the increase in fibrinolysis is due to release of activators from the vessel walls.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3