Factor VII Antigen Levels in a Healthy Blood Donor Population

Author:

Howard P R1,Bovill E G2,Pike J3,Chruch W R3,Tracy R P23

Affiliation:

1. The University of Vermont Department of Medical Technology, Burlington, VT, USA

2. Department of Pathology, Vermont Thrombosis Center, Burlington, VT, USA

3. Department of Biochemistry, Vermont Thrombosis Center, Burlington, VT, USA

Abstract

SummaryWe determined factor VII antigen (FVIIag) levels in 705 healthy blood donors ranging in age from 17 to 79 years using a two-site solid-phase enzyme immunoassay developed in our laboratory. The mean (± SD) FVIIag level for the total population was 102 ± 31%. FVIIag levels for men (n = 375) and women (n = 330) were 101 ± 28% and 103 ± 33%, respectively. A significant increase in FVIIag was observed with age in both men (r = 0.25, p <0.0001) and women (r = 0.35, p <0.0001). FVIIag levels were significantly higher in women > 60 years when compared to men (median women: 125%; median men: 111%; p <0.05). On a subset of the study group (n = 45), FVIIag levels were correlated to total cholesterol (r = 0.27, p = 0.08) and triglyceride (r = 0.41, p <0.01). Assuming the commonly used reference interval of 60-140% for FVII, the frequencies of FVIIag values for <60% and >140% using our assay were 2.1% and 9.2%, respectively. Gender and age-related differences in FVIIag levels must be considered in a reference interval. We further suggest that assay-specific reference ranges be established, which may include values outside the commonly used values of 60-140%.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

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