Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator-Reference-Cited by-同舟云学术

Purification of a Specific Placental Plasminogen Activator Inhibitor by Monoclonal Antibody and Its Complex Formation with Plasminogen Activator

Published:1985 Issue:01 Volume:53 Page:122-125
ISSN:0340-6245
Container-title:Thrombosis and Haemostasis
language:en
Short-container-title:Thromb Haemost

Author:

Åstedt B¹,Lecander Ingegerd¹,Brodin T²,Lundblad A²,Löw Karin²

Affiliation:

1. The Research Laboratories of the Department of Gynecology and Obstetrics, University Hospital of Lund, Lund, Sweden

2. The Department of Clinical Chemistry, University Hospital of Lund, Lund, Sweden

Abstract

SummaryA monoclonal antibody of IgG2a-type was obtained against a specific fast acting plasminogen activator inhibitor found in placenta. The placental inhibitor was purified by affinity chromatography using the monoclonal antibody and additionally in a FPLC-system. A strong complex formation was found between the inhibitor and urokinase and also with the two-chain form of plasminogen activator of the tissue-type. A weaker complex was found between the placental inhibitor and the one- chain form of the tissue-type activator.

Publisher

Georg Thieme Verlag KG

Subject

Hematology

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0038-1661250.pdf

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