Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats

Author:

Safi Elem1,Ficklscherer Andreas1,Bondarava Maryna1,Betz Oliver1,Zhang Anja1,Jansson Volkmar1,Müller Peter1

Affiliation:

1. Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany

Abstract

Purpose The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats. Methods Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery. Results Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons. Conclusion Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons. Clinical Relevance Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.

Publisher

Georg Thieme Verlag KG

Subject

Rehabilitation,Orthopedics and Sports Medicine,Surgery

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